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Does NMN Reverse Aging?

by: Adam Singfield
June 19, 2023

The anti-aging industry is seeing the unstoppable rise of nicotinamide mononucleotide (NMN) because of its proven health and longevity benefits. While how quickly you age will depend on biological factors, your lifestyle, and what you eat, studies show that introducing NMN supplements can reverse signs of aging.

However, you’ll want to do ample research on NMN before purchasing supplements. In this guide, you’ll learn how NMN reverses the signs of aging, how to choose the right supplement, and how to incorporate it into your daily routine.

What Is NMN?

Nicotinamide mononucleotide (NMN) is a component of vitamin B3 present in living cells. It controls everyday bodily functions like metabolism and gene expression by using cellular energy. NMN synthesizes nicotinamide adenine dinucleotide (NAD+) to achieve these functions.

As you age, the amount of NAD+ in the human body decreases, slowing cell division and stimulating the aging process. By 50, most people only have half the amount of NAD+ they had in their 20s.

You can consume NMN naturally from fruits, vegetables, and beef. However, achieving the daily recommended dose of 250 mg is nearly impossible, so taking NMN supplements can increase your intake.

What Happens When The Body Stops Producing NMN?

As NMN production in the body slows, age-related NAD+ decline occurs. The older you get, the more likely you are to experience the following:

  • Metabolic disorders like diabetes, obesity, and liver disease
  • Alzheimer’s disease and dementia
  • Mitochondrial dysfunction
  • Cognitive impairment
  • Infertility
  • Age-associated physiological decline

What Happens When You Age?

Aging is inevitable, but not everyone is prepared for its adverse effects. These age-related changes affect your internal functions and appearance. If you want to be ready as you age, you should understand the process first.

Types Of Aging

Remember, aging affects how you look and how you feel. How you change physically might differ from how you change mentally. Below are the three primary types of aging.

Biological

As your cells age, they lose the ability to support biological functions fully. They divide, multiply, and perform much slower, affecting vital organs, joints, and digestion. The slower your cell metabolism, the more challenging it’ll be for your body to fight off infections and viruses.

It is possible to slow the biological aging process by getting regular exercise, sleeping the appropriate number of hours, adhering to a balanced diet, and undergoing regular medical screenings.

Psychological

Psychological aging refers to how you behave and perceive things as you age. When you get older, your brain changes, and you slowly lose cognitive abilities.

Sometimes, how you age biologically can influence how you age psychologically. For instance, people suffering from physical conditions are more likely to develop depression. Similarly, untreated illnesses can directly affect how someone perceives their environment.

Environmental

People exposed to certain conditions may age faster than others. For instance, environmental factors that can speed up aging include:

  • Air pollution
  • Smoking
  • UV exposure
  • Malnutrition
  • Alcohol consumption
  • Drug use

How Aging Affects The Body

Not every part of the body ages at the same pace. As cells age, how they support certain functions and parts of the body may not degrade as quickly. Here is what you could expect:

Bones & Joints

As you lose bone density, you also lose the ability to absorb vitamin D and calcium efficiently. As a result, you become more likely to develop osteoporosis. In women, bone density loss is faster after menopause because of decreased estrogen production.

Some bones deteriorate faster than others. For instance, the most affected bone is typically the femur, followed by the arm, wrist, and spine bones. When your vertebrae lose density, you also lose height.

Along with aging bones come aging muscles, which become less elastic and can make the joints feel stiff. When you tear a ligament or tendon, it takes much longer to heal.

Heart & Blood

When the blood vessels stiffen, filling the heart with blood takes longer, making it more difficult for arteries to expand. Because the heart has to work harder to pump blood, blood pressure often rises.

Older hearts don’t have the stamina to exercise for longer and may take longer to recover from an illness. Overall, energy levels drop.

Skin

Over time, the skin loses collagen and elastin, making it thinner, drier, and wrinkled. Fat layers in the skin also become more delicate, making it difficult for older people to control their body temperature. Less heat leaves the body, putting you at risk of heat stroke.

In addition, melanocytes, or pigment-producing cells, no longer produce as much, leaving the skin with less protection against ultraviolet radiation.

People more exposed to sunlight are at higher risk of vitamin D deficiencies. The skin may also appear blotchy and wrinkled.

Eyes

Changes in vision become more clinically significant as the body ages. The lens stiffens, yellows, and becomes denser, making it difficult to focus on objects clearly, see in the dark, or perceive colors accurately. Older people also experience impaired depth perception and dry eyes.

It becomes more difficult to discern fine details, and you may even have a speckled field of vision.

Muscles & Fat

By age 30, the skeletal muscle layer begins to lose mass, which impedes a person’s ability to engage in strenuous physical activity. People with sedentary lifestyles tend to lose muscle mass faster than healthy adults.

By 75, you develop twice the body fat you would’ve had in your 30s. Extreme age-associated weight gain can increase the risk of diabetes and cardiac problems.

Reproductive System

The effects of aging are typically more evident in women than in men. During menopause, estrogen production decreases significantly, causing the ovaries and uterus to shrink. Vaginal tissues are thin, become drier, and less elastic, potentially causing pain and discomfort.

In men, dipping hormone levels tend not to be as drastic. However, age-related reduction in testosterone can cause erectile dysfunction, vascular disease, or other metabolic disorders.

The Anti-Aging Benefits Of NMN

Many consumers know that NMN can slow down aging, but how does it do this exactly? Here are a few anti-aging benefits of NMN that show the supplement in action.

Cellular Health

As people age, the number of stem cells in the body decline, and they can no longer effectively maintain tissues. Thankfully, NMN encourages the self-renewal of stem cells, DNA repair, red blood cell production, and increased hemoglobin levels.

NMN can also rejuvenate old blood vessels, as proven by a placebo-controlled study involving rats. This 2016 study divided tester mice into active and placebo groups, providing the active group with NMN. Blood vessels of the older mice receiving NMN were considerably less dilated and impaired, reversing oxidative stress and vascular dysfunction. On the other hand, the placebo group experienced damaged liver and DNA cells.

This study proves that NMN keeps mitochondrial cells healthier and improves cognitive function.

Brain Health

Many age-related diseases can cause cognitive decline, negatively impacting bodily functions like memory and alertness.

Because NMN improves blood flow in the brain, it can have a pronounced nootropic effect. In a clinical research study by Redox Biology in 2019, aged mice that were given NMN demonstrated improved cognitive function and working memory.

In addition, by increasing NAD+ levels and decreasing plaque build-up, NMN can prevent Alzheimer’s disease. As nerve cells keep from degenerating, long-term use of NMN reduces brain fog and fatigue.

Cardiac Health

Because NMN increases NAD+ levels in the heart, supplement takers experience enhanced vascular function, improving physical aspects such as endurance, stamina, and a fast-recovering heart rate. This therapeutic drug can also prevent cardiac-related diseases like heart failure and ischemia.

Eye Health

The older you get, the quicker the area around the retina breaks down, potentially causing macular degeneration. In severe cases of macular degeneration, you can develop blindness.

When you take NMN, it repairs mitochondrial dysfunction, reduces inflammation, and increases oil production to keep the eye healthy and moistened.

Weight & Metabolism

People who naturally produce higher levels of NAD+ have faster metabolisms, earning NAD+ the title of “skinny gene”. However, insulin sensitivity cannot utilize blood glucose or turn fat into energy.

Taking NMN can significantly decrease fat mass and regulate glucose intolerance, especially if you have a slower cell metabolism and are prone to age-related weight gain. Plus, NMN can regulate blood sugar levels, improving insulin resistance and cholesterol levels and creating additional fat.

Muscle Endurance

Skeletal muscles are responsible for controlling strength, stability, and movement. As muscles lose their ability to regenerate, people have lower endurance and become more prone to fatigue. Fortunately, NMN can help combat these effects, as its transporters are proven to increase strength, enhance oxygen utilization, and improve exercise endurance.

Longevity

Perhaps the most desired effect of NMN is longevity, as the supplements can boost SIRTs that promote gene expression and anti-aging.

In post-menopausal subjects, NMN reverses infertility, normalizing DNA and chromosomes that enable reproduction even at a later age. In addition, NMN also improves hair, nails, and skin.

NMN vs NAD

You can’t produce NAD+ without NMN. However, they are different molecules with the following differences:

  • NAD+ has a stronger effect on the brain and mental health.
  • NMN is ideal for physical enhancements.

Taking NMN elevates NAD+ levels, so you get the best of both worlds.

Side Effects Of NMN

Until now, there have been no observed side effects caused by NMN. In recent clinical trials performed in Japan, subjects were given a single oral administration of NMN in 100, 250, and 500 mg doses. No subjects demonstrated clinical symptoms affecting the heart rate, blood pressure, and oxygen saturation.

That said, improperly storing your NMN supplements can negatively impact the body. If you expose your supplements to hot temperatures, the NMN can transform into nicotinamide, which can cause toxicity.

The best way to avoid potential side effects is to store your NMN in a cool, dry area or inside a fridge.

How To Introduce NMN Into Your Anti-Aging Routine

There are two ways to take NMN:

  • As an orally administered supplementation
  • As a sublingual supplement

If you take NMN orally, you can take it in capsule form or mix it into your food or drink. Alternatively, ingesting NMN sublingually diffuses the product directly into the bloodstream through the soft tissue.

How much NMN you take will also depend on your age and health. Generally, people below 35 should take 250 mg/day, increasing to 500 mg/day after one to two weeks. If you are older than 35, the recommended dose is 500 mg/day until you can comfortably increase your intake to 1 g/day.

The best time to take your NMN supplement is after breakfast to increase absorption throughout the day.

While you can break down an NMN capsule, most healthcare professionals recommend against it, as doing so doesn’t improve absorption.

Store your NMN in a cool, dry place away from children.

Taking NMN With Other Supplements

Some people enhance the anti-aging effects of NMN by taking it alongside other supplements. However, not every specialist will recommend taking NMN on its own. If you already take other supplements, here is what you should know about mixing NMN.

NMN & TMG

Like NMN, trimethylglycine is an amino acid that facilitates cardiovascular processes and prevents neurodegenerative diseases. NMN and TMG work well together because TMG requires NMN-produced NAD+ to promote healthy heart function.

NMN & Household Ingredients

Some people take their NMN with a tablespoon of extra virgin olive oil containing oleic acid. Oleic acid is an ingredient that boosts SIRTUIN gene activity and has anti-aging properties.

How To Choose The Right NMN Supplement

Like any new product you are unfamiliar with, the best way to shop for an NMN supplement is to do your research beforehand. Remember these tips when choosing an NMN supplier.

Find A Reputable Supplier

It isn’t always easy to determine whether a company is reputable, so take the extra step of reviewing ratings on the Better Business Bureau. The BBB reflects company ratings and displays customer feedback. More importantly, it highlights past complaints and whether the company did anything to remedy its negative reviews.

Reputable companies also collaborate with board-certified longevity scientists. However, doing additional research on these consultants is imperative. Check whether these scientists are connected to a lab, university, or company, and don’t hesitate to reach out to these establishments for reviews.

Review Product Purity

The best NMN supplements have 99% or higher purity and are relatively unadulterated with other elements. However, as less reputable companies measure purity subjectively, be wary of new or unreviewed brands that make hyperbolic claims about their product.

Many brands will measure purity by comparing their products with others instead of measuring the absolute purity of the actual product. Trust brands that do objective purity testing.

Check For Third-Party Testing

Look for a company that submits its products to independent labs for third-party testing. At these labs, specialists check for contaminants like heavy metals, toxins, yeast, mold, and bacteria. However, not all labs will test for each contaminant – some will test exclusively for heavy metals, while others will test exclusively for toxic microorganisms.

Like you would with a potential NMN supplier, do further research on these labs as well.

Review Pricing

How much a supplement is can say a lot about the supplement itself. With NMN, you often get what you pay for, so cheap supplements can come with potential health hazards.

Buy Only New Generation NMN

Not all NMN supplements are identical. Because NMN is a relatively fragile element, exposing it to water can transform it into nicotinamide (NAM).

Look For A Customer Satisfaction Guarantee

Even a reputable business can’t guarantee that NMN will be effective for you. As such, you can mitigate any risk by shopping with a company that offers a guarantee of compensation. Most businesses will provide a money-back guarantee if you are dissatisfied with the product and return it within a specific period.

The Future Of NMN

While nicotinamide mononucleotide (NMN) research is still in its infancy, clinical trials have proven its efficacy in anti-aging products. Now, scientists are looking to expand its clinical trials from aging mice to humans.

In addition, dermatological groups see NMN as a future development for beauty products, while other healthcare professionals see its potential in sports and exercise recovery.

Upcoming clinical trials aim to study NMN’s effect on sleep, immunity, and overall cognitive function.

The Bottom Line

By increasing NAD+ production via NMN anti-aging drugs, people can experience healthy longevity, faster energy metabolism, and a strengthened immune system for longer.

If you want to rejuvenate your body and slow aging, Pure NMN can help you maximize statistically significant changes that you can see and feel.

Frequently Asked Questions About NMN

How long does it take for NMN to start showing results?

NMN can increase NAD+ production in the body as quickly as 60 minutes. That said, the supplement can take two to three weeks to rejuvenate the endothelial cells and demonstrate visible effects.

This period might vary depending on your biological predispositions and lifestyle. Healthy individuals on a balanced diet and who get regular exercise are more likely to experience the beneficial effects of NAD+ faster.

What is the best way to take NMN for anti-aging?

The best delivery way to take NMN for anti-aging is sublingual, as it enters the bloodstream quicker than a pill.

When should you start taking NMN to slow the aging process?

Most healthcare providers and dermatologists recommend taking NMN by 30, which is when your metabolism starts to slow. However, you can safely take NMN earlier and even after the age of 65.

Can you take NMN with other anti-aging supplements?

Yes, NMN is safe to take with other anti-aging supplements. However, using NMN exclusively for anti-aging will typically suffice.

How can you boost the anti-aging effects of NMN?

You can boost the anti-aging effects of NMN through a balanced diet of fiber-rich food, regular exercise, ample sleep, and an effective skincare routine.

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